Most common cause of raised MSAFP is mistaken dates.
Triple screen for antenatal diagnosis of Down's syndrome uses MSAFP, Unconjugated estriol (both are decreased in Down's) and Serum beta HCG (Increased in Down's)
All 3 are decreased in Trisomy 18.
Inhibin levels and Nuchal translucency thickness are other parameters used to increase sensitivity of Down's syndrome screening.
Chorionic villus sampling is possible earliest by 10-12 weeks gestation.
Amniocentesis is possible earliest by 14-16 weeks gestation.
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